Therapy using Abs. This is therapy by way of antibody action. Vaccines are the best example because they are a way of making the body produce antibodies to a disease antigen, like a virus. The flu shot, given every year, is a prime example.
Targeted therapy. The body's immune system normally makes antibodies that kill viruses, bacteria and even cancer cells. We have learned to make antibodies that are very specific to different cancers and we can add extra drugs to them that are only delivered to the cancer cells. Thus, we have "targeted" therapy to the specific cancer. These drugs show great promise alone or in combination with regular chemotherapy.
Biologics. There are several types of therapy that include antibodies. The two most common would be antibody replacement therapy with igg antibodies for immunodeficiency, and specific antibodies designed with to affect a specific disease process that is immunologically mediated such as rheumatoid arthritis or allergic asthma.
Antibody therapy?? Do you mean immunoglobulin therapy? That is the infusion, either intravenously or subcutaneously, of pooled igg antibodies (aka immunoglobulin). It is used for primary immunodeficiency but also many other rheumatologic disease and hematologic disease.
Several. With monoclonal antibody therapy, severe immune dysregulatory events can occur. These events range from anaphylaxis to immunodeficiency to autoimmunity. Read your pi of your proposed medication and seriously discuss this with your physician.
Really depends upon. The antibody you are receiving and to some extent the reason why you are getting it. You can and should ask the doctor prescribing the antibody for a full disclosure of all potential adverse effects. You can then decide if the potential benefits of monoclonal antibody therapy outweigh the risks. You can also google the antibody name followed by "adverse effects".
Sometimes. Some types of high risk neuroblastomas do qualify for treatment with certain kinds of antibody therapy. However, due to the complicated nature of this cancer treatment is very case-specific and not all neuroblastoma cases will be approached with this treatment modality.
No. Neuroblastoma is treated with a combination of surgery, radiation and chemotherapy.
High risk, after BMT. The monoclonal antibody therapy s designed to be given to patients who have 1) high risk disease (stage IV and some stage iii), 2) great response to chemo/surgery/radiation, 3) have recently had high dose chemo and have received stem cell rescue (aka bone marrow transplant). The treatment is intended to treat only microscopic disease. It can also be very toxic.
No. Neuroblastoma is not an infectious disease and therefore does not respond to antibiotics.
See references. The treatment of neuroblastoma with targeted antibody therapy appears to be available on various research protocols underway at the memorial sloan kettering cancer center in new york. Local physicians may be able to enrole a kid on a study by establishing a relationship with the center. For additional info: see: www. Mskec. Org ; for parent info see: www. Cncfhope. Org.
A great tool. Monoclonal antibodies are anticancer agents designed to bind to a unique protein (the antigen) on cancer cells. Ideally, this antigen is found only on the cancer cells, so our therapy is able to target the cancer cells while causing minimal harm, hence side effects, to normal tissues.
Good targets. Cancer cells "look" different than normal cells; in other words, they display different proteins on their outside compared to normal cells. Antibodies latch onto proteins and can prevent those proteins from functioning, or they can attract the immune system to kill those cancer cells. So that's a quick overview of how antibody therapy can be used to treat cancer.
Targeted Rx. Some tumor cells have markers on their surface and are susceptible to damage by antibodies directed at that marker (s). In some lymphomas antibodies directed at markers present on normal cells are also effective. Usually these are monoclonal antibodies that have been specifically designed for use in humans.