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How does the human brain produce neurotransmitters such as acetylcholine?

2 doctors weighed in
Dr. Ralph Morgan Lewis
Family Medicine
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In brief: ACH synthesis brain

Ach in the brain is produced from acetyl-coa (from glucose metabolism) & from choline, which is actively transported across blood-brain barrier. Most dietary choline comes from phosphatidyl choline (major phospholipid in membranes of plants&animals) acetyl-coa & choline are independently synthesized in neuron cell body & transported along axon to synapse where they are joined into acetylcholine.

In brief: ACH synthesis brain

Ach in the brain is produced from acetyl-coa (from glucose metabolism) & from choline, which is actively transported across blood-brain barrier. Most dietary choline comes from phosphatidyl choline (major phospholipid in membranes of plants&animals) acetyl-coa & choline are independently synthesized in neuron cell body & transported along axon to synapse where they are joined into acetylcholine.
Dr. Ralph Morgan Lewis
Dr. Ralph Morgan Lewis
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Dr. Ralph Morgan Lewis
http://themedicalbiochemistrypage.org/nerves.php
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