Does the skin rash from the later stages of syphilis only affect the palms and soles?

Syphilis. The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, and tertiary). The primary stage classically presents with a single chancre (a firm, painless, non-itchy skin ulceration), secondary syphilis with a diffuse rash which frequently involves the palms of the hands and soles of the feet, latent syphilis with little to no symptoms, and.
No. Involvement of the palms and soles is a hallmark of secondary syphilis, but lots of other rashes can also involve those areas. Back in the day, syphilis was known as "the great imitator", because it often masqueraded as other diseases. With the advent of penicillin and other modern antibiotics, syphilis has become relatively rare - at least in this country.