On Zoloft 75mg and wellbutrin (bupropion) 150sr. Gained 45 pounds from it. I cut calories down from 3, 000 a day to 1, 500 for a mnth with no weight loss. Help.?

Don't give up. Im surprised you didn't gain more than 45 pounds on 3000 calories a day. Even though you haven't lost weight, did you stop gaining when you cut back? Depending on your height and level of activity, you may need to cut back some more. If you are 5'6" or less and sedentary, 1500 calories will maintain your weight.
Wt. Been evaluated by pcp for other physical causes of wt. Gain?. Other medications besides zoloft (sertraline) tried before?. Discuss all options with your doc.