1 doctor weighed in:

Are elevated tissue transglutaminase antibodies a possible reason for sneddons syndrome because of their effect on thrombin and the endothelia lining?

1 doctor weighed in
Dr. Ed Friedlander
Pathology

In brief: Bad fit

Glad you're interested in basic pathology.
Not a bad conjecture. But if this were the case, sneddon's would run with gluten enteropathy. It doesn't. Under the microscope, sneddon's is a proliferative endarteritis with lymphocytes and macrophages, not what we see in antibody-antigen mediated vasculitis.

In brief: Bad fit

Glad you're interested in basic pathology.
Not a bad conjecture. But if this were the case, sneddon's would run with gluten enteropathy. It doesn't. Under the microscope, sneddon's is a proliferative endarteritis with lymphocytes and macrophages, not what we see in antibody-antigen mediated vasculitis.
Dr. Ed Friedlander
Dr. Ed Friedlander
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