4 doctors weighed in:
How common is lactic acidosis with sepsis?
4 doctors weighed in

Dr. William Walsh
Addiction Medicine
2 doctors agree
In brief: With septic shock
It is a marker for end organ damage due to inadequate oxygen reception or utilization.
When sepsis progresses to shock we will follow lactate (its pka is 4, so its never really acid in the blood) as a marker of our success in getting blood and oxygen to the peripheral tissues. So... In sepsis itself (without shock) it is rare, but in septic shock lactate is almost always elevated.

In brief: With septic shock
It is a marker for end organ damage due to inadequate oxygen reception or utilization.
When sepsis progresses to shock we will follow lactate (its pka is 4, so its never really acid in the blood) as a marker of our success in getting blood and oxygen to the peripheral tissues. So... In sepsis itself (without shock) it is rare, but in septic shock lactate is almost always elevated.
Dr. William Walsh
Dr. William Walsh
Thank
1 comment
Dr. William Walsh
Lactate itself does not cause the acidosis, FYI - it is an excess of HC03 that generally leads to a low pH. Lactate raises stoichiometrically with tissue hypoxemia, so its used as a marker rather than a cause of acidosis.
Dr. Ziad Akl
Internal Medicine - Infectious Disease
In brief: Common
Any time blood flow to tissues drops, there is production of lactic acid.
Sepsis can cause blood flow to decrease because of a drop in blood pressure or because of clotting in small blood vessels.

In brief: Common
Any time blood flow to tissues drops, there is production of lactic acid.
Sepsis can cause blood flow to decrease because of a drop in blood pressure or because of clotting in small blood vessels.
Dr. Ziad Akl
Dr. Ziad Akl
Thank
Get help from a real doctor now
Dr. William Forsythe
Board Certified, Emergency Medicine
23 years in practice
171K people helped
Continue
107,000 doctors available
Read more answers from doctors