Can I reduce my chance of sepsis if I wash my hands thoroughly?

Well maybe. Hand washing may decrease your risk of getting infections like the flu. In some cases the flu can lead to secondary infections like pneumonia that are associated with sepsis. So hygiene is always a good thing. Most cases of sepsis are caused by other problems, pneumonia from aspiration of germs in the mouth, belly diseases such a gall bladder disease, etc. Often in those with chronic diseases.