3 doctors weighed in:

Is luvox (fluvoxamine) the only ssri that promotes melatonin yet interferes with caffeine?

3 doctors weighed in
Dr. Pamela Pappas
Psychiatry
2 doctors agree

In brief: Luvox (fluvoxamine)

You're referring to luvox (fluvoxamine)'s ability to inhibit the liver enzyme cyp1a2, which is needed to process both caffeine and melatonin.
Both of these substances could build up to greater concentrations than expected, when taken with luvox (fluvoxamine). It is the only ssri that acts in that manner, but there are multiple other drugs that do this also.

In brief: Luvox (fluvoxamine)

You're referring to luvox (fluvoxamine)'s ability to inhibit the liver enzyme cyp1a2, which is needed to process both caffeine and melatonin.
Both of these substances could build up to greater concentrations than expected, when taken with luvox (fluvoxamine). It is the only ssri that acts in that manner, but there are multiple other drugs that do this also.
Dr. Pamela Pappas
Dr. Pamela Pappas
Thank
Dr. Heidi Fowler
Psychiatry

In brief: Luvox

“It has been suggested that the beneficial effects of fluvoxamine on sleep may be related to its inhibitory effect on melatonin degradation; this effect has not been observed with other SSRIs (85, 86).
” REF: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1448696/



In brief: Luvox

“It has been suggested that the beneficial effects of fluvoxamine on sleep may be related to its inhibitory effect on melatonin degradation; this effect has not been observed with other SSRIs (85, 86).
” REF: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1448696/


Dr. Heidi Fowler
Dr. Heidi Fowler
Thank
Get help from a real doctor now
Dr. Bennett Machanic
Board Certified, Neurology
49 years in practice
56M people helped
Continue
111,000 doctors available
Read more answers from doctors