Can calf pain, knee pain in both legs be caused by poor shoes? 2 negative d dimer

Yes. If the question is can poor shoes cause those problems, the answer is yes and very common. Due to leg adjustment to walking and causing strain in those areas. Is it the actual cause in you is a bigger question as it is difficult to surmise that without proper examination. The treatment is change shoes and if you feel the difference, then you can come to a conclusion.