Does taking provigil or nuvigil for cfs have a negative effect on life expectancy?

I don't know. Neither drug has been out long enough to know. As far as we can. Tell, however, there is nothing that would indicate that there should be cause for concern.. On the other hand, the stress on the system of untreated cfs could be a cause for concern because of the lack of physical conditioning that could otherwise set in over time as well as the long term psychological effects of the syndrome.