I took diflucan (fluconazole) pill 200mg on monday and now I have red itchy heated painful spot in the palm of my right hand and it itches and burn so bad?

Fluconazole. It is unlikely that the palmar lesion is in any way related to the fluconazole, but the bes thing to do is to have this seen by a dermatologist or your psp and diagnosed after an exam. Good luck.