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Why does remeron and Benadryl and products with benedryl in them, like tylenol (acetaminophen) pm; give me restless legs so bad I wind up in tears sometimes?

Dr. John Chiu, University of Vermont College of Medicine Answered Jan. 23, 2014
55 years experience in Internal Medicine - Allergy & Immunology
Don't know. But you should avoid these medications regardless of the mechanism. To be noted is that both drugs have antihistaminic and anticholinergic activities .
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111,000+
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7 billion+
Answers served
Doctors in our network have worked for:
Ucsf-medical Ucla-health Johns-hopkins-university
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Wired Wsj Nbc
Ios_consumer_app_icon
16,309 Ratings
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  • Currently on hydrocodone 5mg plus acetaminophen 325mg pills for pain after hand surgery. Is it safe to take a Benadryl (diphenhydramine) a day as well?
  • Gi advised me to take 50 gm of Benadryl & 1000mg of tylenol (acetaminophen) prior to next remicade infusion to prevent post reaction leg ache I had last. Any advice?
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  • Would it be safe to take benadryl, Tylenol (acetaminophen) PM or something to help me fall asleep temporarily? I have Wolff Parkinson white syndrome!!
  • Safe to take Tylenol (acetaminophen) PM or Benadryl hours after taking Trileptal? Ate something that's making me itchy as well as chest pains from heavy lifting.
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  1. Home
  2. → Health Answers
  3. → Benadryl
  4. → Take Benadryl Diphenhydramine
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HealthTap © 2017