I have ms. Had chills for an hour with no fever. Happened before. Can chills come with ms? I have a small lesion in my brain stem that isn't active

Check for infection. Chills are more commonly associated with possible urinary tract infection or systemic infection. Have your doctor culture urine and maybe get chest x-ray. Also, perhaps get liver function testing, as rarely, Copaxone (glatiramer) could cause an immune hepatic problem. (additional advice, if not taking vitamin d-3 supplements, you should do so, about 5000 units twice daily).