4 doctors weighed in:

Should cymbalta (90/day) and nucynta (tapentadol) ER (300/day) be taken together?

4 doctors weighed in
Dr. Donald Jacobson
Psychiatry
2 doctors agree

In brief: They are both long

Acting enough that the timing is likely irrelevant.
www.drugs.com has the following warning on any combination of sedating meds.Monitor: central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients. Best to discuss with your own physician who knows the details of your physical condition. Best wishes.

In brief: They are both long

Acting enough that the timing is likely irrelevant.
www.drugs.com has the following warning on any combination of sedating meds.Monitor: central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients. Best to discuss with your own physician who knows the details of your physical condition. Best wishes.
Dr. Donald Jacobson
Dr. Donald Jacobson
Thank
Dr. Thomas Steele
Psychiatry

In brief: Potential problems

Those are fairly high doses of each.
There is a risk of excess sedation, but also a more serious potential risk of serotonin syndrome. This is the sort of question that should really be discussed with your prescriber!

In brief: Potential problems

Those are fairly high doses of each.
There is a risk of excess sedation, but also a more serious potential risk of serotonin syndrome. This is the sort of question that should really be discussed with your prescriber!
Dr. Thomas Steele
Dr. Thomas Steele
Thank
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