Started on cipro (ciprofloxacin) yesterday for kidney infection. I'm more tired and drained today than yesterday. Is this normal?

Kidney infection. Possibly Cipro (ciprofloxacin) has not had time to act ! your symptoms may be due to the 'kidney inf' not Cipro (ciprofloxacin) ! it can cause stomach upset, headache, restlessness, and rash. Uncommonly, may cause seizures and kidney failure ! if you are not better by 48 hrs follow up with your physician.