4 doctors weighed in:

How does klonopin (clonazepam) affect serotonin?

4 doctors weighed in
Dr. Donald Jacobson
Psychiatry
2 doctors agree

In brief: Klonopin (clonazepam) does effect

Serotonin receptors.
It decreases the serotonin available in the synapse by upregulation of the serotonin transporter which whisks serotonin out of the synaptic space. It's mechanism of actions is therefor diametrically opposed to that of ssri's which block the re-uptake transporters. Adv neurol 43: 629–43. Pmid 2418652.

In brief: Klonopin (clonazepam) does effect

Serotonin receptors.
It decreases the serotonin available in the synapse by upregulation of the serotonin transporter which whisks serotonin out of the synaptic space. It's mechanism of actions is therefor diametrically opposed to that of ssri's which block the re-uptake transporters. Adv neurol 43: 629–43. Pmid 2418652.
Dr. Donald Jacobson
Dr. Donald Jacobson
Thank
2 comments
Dr. Pamela Pappas
Thanks, Dr. Jacobson. I love learning things I forgot or never knew! Sounds like this supports the idea that using Klonopin may not be wise when people are depressed -- at least if you believe that increased serotonin in synapses is why SSRI's work. Best wishes.
Dr. Donald Jacobson
This could be one of the reasons Klonopin can cause a depressive reaction.
Dr. Pamela Pappas
Psychiatry
1 doctor agrees

In brief: It doesn't

Klonopin (clonazepam) does not work via serotonin.
Like other benzodiazepines, it binds to gaba-a receptors ; complexes, causing inhibition of neuronal firing at the level of the limbic system, the brain stem reticular formation, and the cortex. Anti-anxiety activity comes first, then anticonvulsant effects, next a reduction in muscle tone, and finally sedation. It induces tolerance and habituation too.

In brief: It doesn't

Klonopin (clonazepam) does not work via serotonin.
Like other benzodiazepines, it binds to gaba-a receptors ; complexes, causing inhibition of neuronal firing at the level of the limbic system, the brain stem reticular formation, and the cortex. Anti-anxiety activity comes first, then anticonvulsant effects, next a reduction in muscle tone, and finally sedation. It induces tolerance and habituation too.
Dr. Pamela Pappas
Dr. Pamela Pappas
Thank
Read more answers from doctors