How does klonopin (clonazepam) affect serotonin?

Klonopin (clonazepam) does effect. Serotonin receptors. It decreases the serotonin available in the synapse by upregulation of the serotonin transporter which whisks serotonin out of the synaptic space. It's mechanism of actions is therefor diametrically opposed to that of ssri's which block the re-uptake transporters. Adv neurol 43: 629–43. Pmid 2418652.
It doesn't. Klonopin (clonazepam) does not work via serotonin. Like other benzodiazepines, it binds to gaba-a receptors ; complexes, causing inhibition of neuronal firing at the level of the limbic system, the brain stem reticular formation, and the cortex. Anti-anxiety activity comes first, then anticonvulsant effects, next a reduction in muscle tone, and finally sedation. It induces tolerance and habituation too.

Related Questions

Does klonopin (clonazepam) raise or lower serotonin?

Benzodiazepines. Directly affect GABA, and at least in rats, they decrease serotonin (and affect the various serotonin receptors) through a complex mechanism. This may be in part why they can be effective in treating serotonin syndrome and why they can complicate mood disorders in certain patients. Read more...

How can I tell if I have serotonin syndrome or if I was just sick. I take lithium, cymbalta, (duloxetine) requip, tramadol, trazadone, and klonopin which don't mix.

Call psychiatrist. You might start with the prescribing physician who i hope is a psychiatrist with this combination of psychiatric meds. If not, i would recommend you see a psychiatrist asap. Read more...

Taking evekeo, wellbutrin, luvox, klonopin (clonazepam) and getting headaches. Could I be at risk for serotonin syndrome?

Medication effects. I understand your concern . Luvox is a SSRI Medication and may cause Serotonin Syndrome. Your Headaches are most likely due to Evekeo (Amphetamine) and Luvox. Taking Wellbutrin (bupropion) with Evekeo and Luvox may increase the risk of seizures See a Psychiatrist for Diagnosis, need for specific medication, Medications benefits and side effects, Medication Interactions ; and Therapy for stress in your life. Read more...

Taking 300mgs luvox, 37.5mgs effexor, (venlafaxine) 10mgs evekeo and 1mg klonopin for depression and anxiety. Am I at risk for serotonin syndrome?

Drug Interactions. Effexor plus luvox together may increase risk of serotonin syndrome per Drugs.Com drug interaction checker. For full information about potential of each of these medication to interaction with each other see: https://www.drugs.com/interactions-check.php?drug_list=2296-1524,2543-17160,703-357,1128-9754. Read more...