How does klonopin (clonazepam) work on serotonin? I've heard it can contribute to depression. How so?
Klonopin (clonazepam) Although klonopin's main action is on gaba-a receptors leading to inhibition of neuronal impulses, it also affects serotonin. It decreases 5ht utilization in the brain as well as egress of 5-hiaa from the brain. Http://tinyurl. Com/muqaacu it apparently upregulates serotonin transporters which do the opposite of ssri's -- take serotonin out of the synapse. Voila -- maybe more depression.
See details. It has not effect on serotonin. It can contribute to depression because it is a tranquilizer.