5 doctors weighed in:

Why is cryofibrinogenemia associated with lymphoma? Does lymphoma cause cryofibrinogen to appear, or vice versa, or is there no causal association?

5 doctors weighed in
Dr. Ed Friedlander
Pathology
3 doctors agree

In brief: Tumor product

Malignant lymphomas of b-cell origin may produce the abnormal protein that complexes to produce a cryofibrinogen, or may stimulate other cells to do so.
The paraprotein isn't going to mutate your dna to cause lymphoma.

In brief: Tumor product

Malignant lymphomas of b-cell origin may produce the abnormal protein that complexes to produce a cryofibrinogen, or may stimulate other cells to do so.
The paraprotein isn't going to mutate your dna to cause lymphoma.
Thank
1 comment
Dr. Ed Friedlander
The chemistry of cryofibrinogens is still being worked out and some of the molecular players are clearly unknown. We are still discovering previously-unknown proteins produced by lymphomas and other cancers. I predict that one of these will be identified within the next decade and found to account for the clinical association.
Dr. Ted Saha
Palliative Care

In brief: CRYOFIBRINOGENEMIA

Most often associated with an underlying inflammatory disorder, infection, or cancer, but familial primary cases has been described.
Non-hodgekins lymphoma and colorectal cancer are associated. 50% of pt with primary disease will develop lymphoma in the following yr.Lymphoma does not cause cryofibrinogenemia

In brief: CRYOFIBRINOGENEMIA

Most often associated with an underlying inflammatory disorder, infection, or cancer, but familial primary cases has been described.
Non-hodgekins lymphoma and colorectal cancer are associated. 50% of pt with primary disease will develop lymphoma in the following yr.Lymphoma does not cause cryofibrinogenemia
Thank
Dr. Martin Raff
Internal Medicine - Infectious Disease

In brief: Cryofibrinogen

Cryofibrinogenemia is an uncommon blood protein that precipitates when cooledls and then redissolved when warmed.
The disorder can occur for no apparent reason or may be associated with conditions such as cancer, infections and blood clotting disorders, without an obvious reason for its presence or absence. It is unlikely that it has any causal relationship to lymphoma.

In brief: Cryofibrinogen

Cryofibrinogenemia is an uncommon blood protein that precipitates when cooledls and then redissolved when warmed.
The disorder can occur for no apparent reason or may be associated with conditions such as cancer, infections and blood clotting disorders, without an obvious reason for its presence or absence. It is unlikely that it has any causal relationship to lymphoma.
Thank
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