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Please help! what is the mode of inheritance for osteogenesis imperfecta?

3 doctors weighed in
Dr. Anna-Kaisa Niemi
Clinical Genetics
2 doctors agree

In brief: OI mostly dominant

There are many types of osteogenesis imperfecta.
Most are inherited in an autosomal dominant pattern (=one copy of the altered gene sufficient to cause condition). Some inherit it from a parent, others arise spontaneously (sporadic, de novo) in a child. Some types of oi are inherited in autosomal recessive manner which means that each parent is a carrier but does not have symptoms.

In brief: OI mostly dominant

There are many types of osteogenesis imperfecta.
Most are inherited in an autosomal dominant pattern (=one copy of the altered gene sufficient to cause condition). Some inherit it from a parent, others arise spontaneously (sporadic, de novo) in a child. Some types of oi are inherited in autosomal recessive manner which means that each parent is a carrier but does not have symptoms.
Dr. Anna-Kaisa Niemi
Dr. Anna-Kaisa Niemi
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