2 doctors weighed in:

What it the probability that a couple's child will be afflicted with sickle cell anemia if they both carry that trait but don't exhibit it?

2 doctors weighed in
Dr. Scott Diede
Pediatrics - Hematology & Oncology

In brief: 25% chance

If both parents have trait, then the child has a 25% chance of having sickle cell disease, a 50% chance of having trait, and a 25% chance of not inheriting any mutation.

In brief: 25% chance

If both parents have trait, then the child has a 25% chance of having sickle cell disease, a 50% chance of having trait, and a 25% chance of not inheriting any mutation.
Dr. Scott Diede
Dr. Scott Diede
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1 comment
Dr. James Ferguson
That is, for any conception, your baby could have sickle cell. You do not get a pass on the second baby if the first was affected. You roll a 4 sided dice with every conception.
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