Can I take hydrocodone and nyquil at the same time?

Must be cautious. Opioids all can interact with the medications in nyquill, which include an antihistamine, decongestant and cough suppressant. In appropriate prescribed doses there should not be major problems, but some people experience greatly increased dizziness, lightheadedness and even sedation with these combinations. The person to talk to is the prescribing physician or your pharmacist. Don't drive on combo.