Why does Zoloft (sertraline) 100mg cause an acute oculogyric crisis?
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Why does Zoloft (sertraline) 100mg cause an acute oculogyric crisis?
2 doctors weighed in
Dr. Pamela Pappas
Psychiatry
In brief: Usually it doesn't
The resulting increase in serotonergic activity can inhibit both nigrostriatal and tuberoinfundibular dopaminergic neurons, resulting in extrapyramidal symptoms (eps). Balance between these systems is extremely important. Akathisia is the most common kind of eps from zoloft, (sertraline) rather than oculogyric crisis.
In brief: Usually it doesn't
The resulting increase in serotonergic activity can inhibit both nigrostriatal and tuberoinfundibular dopaminergic neurons, resulting in extrapyramidal symptoms (eps). Balance between these systems is extremely important. Akathisia is the most common kind of eps from zoloft, (sertraline) rather than oculogyric crisis.
Dr. Pamela Pappas
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