2 doctors weighed in:

Why does Zoloft (sertraline) 100mg cause an acute oculogyric crisis?

2 doctors weighed in
Dr. Pamela Pappas
Psychiatry
1 doctor agrees

In brief: Usually it doesn't

Zoloft (sertraline) inhibits serotonin reuptake, and in that way can also affect dopamine.
The resulting increase in serotonergic activity can inhibit both nigrostriatal and tuberoinfundibular dopaminergic neurons, resulting in extrapyramidal symptoms (eps). Balance between these systems is extremely important. Akathisia is the most common kind of eps from zoloft, (sertraline) rather than oculogyric crisis.

In brief: Usually it doesn't

Zoloft (sertraline) inhibits serotonin reuptake, and in that way can also affect dopamine.
The resulting increase in serotonergic activity can inhibit both nigrostriatal and tuberoinfundibular dopaminergic neurons, resulting in extrapyramidal symptoms (eps). Balance between these systems is extremely important. Akathisia is the most common kind of eps from zoloft, (sertraline) rather than oculogyric crisis.
Dr. Pamela Pappas
Dr. Pamela Pappas
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