They are cousins. And while both have the same opiate nucleus, one has an oxygen radical and the other a hydroxy radical, which makes them chemically different. They have different properties, with oxycodone 50% more potent, more rapidly absorbed and gets to the brain faster, and with fewer side-effects like flushing, itching and GI symptoms than hydrocodone. They are both metabolized into Codeine and morphine.
Med substitution. Yes, the medications can be used interchangeably.
Dangerous practice. Opiate medications mixed together increase the risk of opiate overdose, which may be fatal.
Everyone's different. They both are very strong and effective pain killers. Oxycodone is a little stronger, but hydrocodone should be strong enough to cover most pain. Some people respond better to hydrocodone and some to oxycodone. It just depends on how much pain relief you experience. Hope that helps!
Different Molecules. They are different molecules totally. Generally speaking oxycodone seems to be a more potent opioid than hydrocodone and therefore stronger.
Molecular structure. Very little difference between the two. Some people metabolize hydrocodone more efficiently than oxycodone so some people may say one is better than the other but they both work exactly the same if metabolized properly.
Similar opiates. Hydrocodone is a semi-synthetic opiod derived from two of the naturally occuring opiates, Codeine and thebaine. Oxycodone is an opioid medication synthesized from thebaine. It does not contain codeine.
Many addictions. Any substance or activity that results in pleasure or the relief of a symptom may become an addiction. About a sixth of the population is prone to this consequence. Both substances are opioids (morpine-like drugs) that can cause death by overdosing, drowsiness, nausea, constipation and endocrine disturbances with chronic use. Death by overdosing is unusual in long-time rx users.
Not likely. They are close cousins, but it depends on the doses of either/both drugs. If a person were taking 8 vicodin per day, and tried to replace it with 2 Percocet per day, they would likely have withdrawal. In equipotent doses (5 mg oxycodone = 7.5 mg hydrocodone) any withdrawal of one would be covered by replacement with the other.