3 doctors weighed in:

How do you deal with chemo-induced neutropenia?

3 doctors weighed in
Dr. Michael Engel
Pediatrics - Hematology & Oncology
1 doctor agrees

In brief: Following

Myelosuppressive chemotherapy, the bone marrow will be compromised in its ability to make neutrophils (a type of WBC that protects against bacterial infections).
Since a neutrophil only lasts 24hrs after its made, you quickly run out if you arent making them efficiently. To facilitate recovery after chemo, we use a gcsf, which stimulates neutrophil production to mitigate infection risk.

In brief: Following

Myelosuppressive chemotherapy, the bone marrow will be compromised in its ability to make neutrophils (a type of WBC that protects against bacterial infections).
Since a neutrophil only lasts 24hrs after its made, you quickly run out if you arent making them efficiently. To facilitate recovery after chemo, we use a gcsf, which stimulates neutrophil production to mitigate infection risk.
Dr. Michael Engel
Dr. Michael Engel
Thank
Dr. Michael Benjamin
Internal Medicine - Hematology & Oncology

In brief: Treat or observe

Depends on the setting.
I was taught in fellowship to treat neutropenia aggressively in a curative situation, and less aggressively in the palliative setting. Gcsf (neupogen) and depot-gcsf (neulasta) are the main meds used, Leukine (sargramostim) (gm-csf) is more toxic and seldom used. Prolonged severe neutropenia (anc<500) can increase risk of infection so is usually treated, except perhaps in leukemia.

In brief: Treat or observe

Depends on the setting.
I was taught in fellowship to treat neutropenia aggressively in a curative situation, and less aggressively in the palliative setting. Gcsf (neupogen) and depot-gcsf (neulasta) are the main meds used, Leukine (sargramostim) (gm-csf) is more toxic and seldom used. Prolonged severe neutropenia (anc<500) can increase risk of infection so is usually treated, except perhaps in leukemia.
Dr. Michael Benjamin
Dr. Michael Benjamin
Thank
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