In what way is a brain biopsy performed?

Brain biopsy. When a diagnosis involving the brain is unclear then a brain biopsy is performed. A small burr hole is created in the skull. Then the dura mater is opened to expose the brain. In some cases, computers provide a 3D mapping of the brain to assist the neurosurgeon in localizing the lesion of interest (stereotactic guidance). Then a biopsy needle or a microscope is used to sample the tissue.