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How can lead poisoning affect erythrocytes at a cellular level?

2 doctors weighed in
Dr. Scott Diede
Pediatrics - Hematology & Oncology
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In brief: Heme synthesis...

Lead inhibits the body's ability to make hemoglobin by interfering with several enzymatic steps in the heme pathway.
Specifically, lead decreases heme biosynthesis by inhibiting d-aminolevulinic acid dehydratase (alad) and ferrochelatase activity.

In brief: Heme synthesis...

Lead inhibits the body's ability to make hemoglobin by interfering with several enzymatic steps in the heme pathway.
Specifically, lead decreases heme biosynthesis by inhibiting d-aminolevulinic acid dehydratase (alad) and ferrochelatase activity.
Dr. Scott Diede
Dr. Scott Diede
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