You can, but not
Recommended. If you hold it on the side of convexity, then you can cause increase pressure on nerve
on the concave side.
If you wear it on the concave side, you may cause micro-trauma leading to further curvature even with the brace. Avoid if possible. There are weight distributing backpacks that cause the weight to distributed off the shoulders and on to waist, consider that or rolling bag.