What else can you do to get rid of a migraine that doesn't disappear after excedrin?

Get Consulttation. Migraine syndrome has multiple treatment options from script medications, imitrex, (sumatriptan) to Botox injections. There are varieties of migraines and symptoms, so would suggest a consultation with a headache specialist to begin therapy. In very severe and frequent migraines, Botox has proven to be helpful in many cases by less frequent, less severe, less duration.