Does wellbutrin (bupropion) affect sex?

It could. Wellbutrin (bupropion) usually has less sexual issues than the other antidepressants and can be used to help the sexual side effects of other drugs. That being said, the pharmacology of wellbutrin (bupropion) is complex and sexual side effects such as decreased sex drive, lack or orgasm and delayed orgasm can occur.
Depends. No sexual side effects in some cases may improve sexual function if decreased due to depression for example also raises Dopamine which may offset problems caused by other meds.