What are the safest and non safest ssri's-snri's to use with plavix-aspirin-cozaar-cardizem cd-vytoryn-onglyza?

Enzyme Inhibition. All of the selective serotonin re-uptake inhibitors are metabolized in the liver.The enzyme system involved is called the p450.During metabolism in liver, ssris inhibit different sub- enzymes, for example, 2d6, 3a1, 3a2, 2d5, etc., leading to decrease in metabolism of other medications, causing increase in their serum levels. Zoloft (sertraline) is the safest ; Prozac ; Celexa are the least safe among ssris.
I'm not aware of any. I'm not aware of any significant interaction but follow up with your primary care doctor or cardiologist.