What is antiphospholipid syndrome?

Blood clots. Antiphospholipid Syndrome (APS) can exist on its own or in association with another autoimmune condition such as lupus. It is caused by antibodies that increase the risk of blood clots. These antibodies also interfere with routine laboratory tests of blood clotting by binding to phospholipids, hence the name. The symptoms of APS can include blood clots, Raynaud's and pregnancy loss.
Short description. It involves arterial or venous clotting or specific pregnancy complications, with laboratory evidence of anti-phospholipid antibodies. Autoantibodies, meaning produced and directed against one's self, are to plasma proteins (many:) altering normal clotting leading to thrombus (clot) and/or pregancy complications like fetal death, recurrent early pregnancy loss, eclampsia, and others.
Abnormal clotting. Apa syndrome is an autoimmune disorder in which the body mistakingly produces antibodies against certain normal proteins in the body. This leads to abnormal clot formation in arteries and veins. A potentially very serious condition.

Related Questions

What leads to antiphospholipid syndrome?

It is autoimmune. Antiphospholipid syndrome (aps) is an autoimmune condition which can be its own entity or associated with other connective tissue diseases such as lupus. A diagnosis requires thorough evaluation by a rheumatologist. Typically, we don't make a diagnosis after one test result. The general rule of thumb is to repeat the test 3 months after the first one to confirm. There is more than one test.
It can be genetic. One can inherit this syndrome, or it may arise without any apparent history or cause. It is associated with multiple medical problems, including recurrent pregnancy loss.

What can trigger antiphospholipid syndrome?

Lupus, stress. Systemic lupus erythematosus, chronic/acute severe stress and genetic predisposition all conspire to lead to antiphospholipid antibody syndrome. This is a very rare but devastating disorder that can have horrible perinatal outcomes with each pregnancy. Considered an autoimmune disorder, apls may have its etiological underpinnings in maternal-fetal cell trafficking, as most autoimmune conditions.

What is differences between Antiphospholipid Syndrome and Sticky Platelet Syndrome? Just found out that I have both of them. On Plavix (clopidogrel) 75mg.

Autoimmune/genetic. Sticky platelet syndrome is an inherited condition affected platelet aggregation. Anti phospholipid syndrome is an autoimmune disorder that can involve multiple different points in the coagulation process, not just platelets. Both tend to be treated with aspirin and sometimes some additional anticoagulant.

What sort of problem is antiphospholipid syndrome?

Autoimmune. Autoimmune means your body produces antibodies - cells that attack your own body. In antiphosopholipid syndrome the antibody which is made provokes blood clots (thrombosis) in both arteries and veins as well as pregnancy-related complications such as miscarriage, stillbirth, preterm delivery, or severe preeclampsia.
APS. To make this diagnosis you need to have abnormal test results at least twice a month apart as well as abnormalities such as recurrent pregnancy loss or blot clots (thrombosis) or pulmonary embolus. If you have not had problems hulu don't have the condition.
Recurrent Preg Loss. Apa are assoictaed with recurrent pregnancy loss where the pregnancy may be rejected or associated with clotting at the placental site. It can be treated with blood thinners.
It is automimmune! Apls can occur in many autoimmune settings (with lupus or spondylitis), or simply by itself. There are three major types of anticardiolipin antibodies. The IgG class is particularly a problem in pregnant females, becuase these antibodies can clot placental vessels. Igm anticardiolipin antibodies are more serious if elevated in non-pregnant adults because of greater arterial clot risk!
Acquired. Antiphospholipid antibodies (apla) are one of the acquired (as opposed to inherited) thrombophilias (conditions that cause blood clotting). As others have said, apla can cause miscarriages. It is unusual amongst the thrombophilias in that it causes venous and artrial clots. At one time, it was thought that lupus was the cause of apla, we now know that you can get apla without having lupus.

What can I expect from "antiphospholipid syndrome"?

Complex problems. The manifestations of aps range from having no symptoms at all to catastrophic, disastrous clotting affecting multiple organs leading to death within days. Many will present with blood clots, some with skin changes, others with low platelets or women will have repeated spontaneous miscarriages. Another autoimmune disorder may also be diagnosed such as lupus erythematosus. See:http://www. Apsfa. Org/.

What are the effects of antiphospholipid syndrome on pregnancy?

Increased risk. Anti-phospholipid antibody syndrome can cause growth restriction, early onset high blood pressure of pregnancy (pre-eclampsia) and blood clots. Your doctor will likely prescribe blood thinners during your pregnancy and follow the babies growth with serial ultrasounds.
Increased risk. Antiphospholipid antibodies increase the risk of miscarriage or stillbirth. Many times anticoagulant meds are given during the pregnancy to reduce these risks.
Fetal loss. There is a high incidence of spontaneous loss of pregnancy (miscarriage) with antiphospholipid syndrome. Likely due to clotting within the placental blood vessels. Anticoagulation can be helpful in preventing this problem.

What other autoimmune diseases, besides antiphospholipid syndrome, cause deep vein thrombosis & increased coagulation of blood?

Lupus. Systemic lupus erythematosus is a rather common one that results in thrombophilia. Other tests that we typically order to test for a propensity to clotting include: protein c, protein s deficiencies, Antithrombin iii deficiency, factor v leiden mutation, prothrombin gene g20210 mutation, in addition to lupus anticoagulant and antiphospholipid antibodies. Consult your physician.
Also. Wegener's and behcet's have an increased risk of thrombosis as well.

Can you explain antiphospholipid syndrome?

Short description. It involves arterial or venous clotting or specific pregnancy complications, with laboratory evidence of anti-phospholipid antibodies. Autoantibodies, meaning produced and directed against one's self, are to plasma proteins (many:) altering normal clotting leading to thrombus (clot) and/or pregancy complications like fetal death, recurrent early pregnancy loss, eclampsia, and others.