Which results have patients experienced from deep brain stimulation for the treatment of Parkinson's disease?
Parkinson's disease. Deep brain stimulation (dbs) for parkinson's disease reduces the tremors, rigidity, and slowness of movement. The dbs does not destroy the surrounding brain, can be programmed with an external computer, and can be turned on and off. The dbs also allows patients to reduce the intake of oral medications.
What percentage of Parkinson's disease patients are good candidates for deep brain stimulation (DBS)?
Parkinson Diseases. DBS is typically reserved for patients with end stage type disease that failing medications. It is not a first line type of therapy.
Actually, . I have met patients who are in their 40's and 50's who have had the procedure. The more we learn, about dbs, and the more cases of parkinson's presenting earlier, suspect we will be utilizing variations of dbs sooner in the disease course. But cannot get success in pts who do not respond to l-dopa.
Average ages. The average age of diagnosis of PD is about 62. The vast majority of my DBS patients are in their 60s. However, I have operated on patients as young as 38 for early onset PD with great results. A thorough evaluation including a and On/Off evaluation and neuropsych testing is needed to determine candidacy at whatever age. Response to LDOPA is also very important.
Yes. Deep brain stimulation can help patients with all three cardinal motor symptoms of Parkinson's disease, including tremor, rigidity (or stiffness), and slowness (bradykinesia). It does not help with non-motor symptoms, balance problems, or freezing.
Further Detail. Deep brain stimulation therapy of the stn (sub-thalamic nucleus) or gpi (globus pallidus interna) can greatly improve "on" time (good function with minimized symptoms) & greatly reduce dyskinesia (twisting, writhing, jerking movements during "on" time). Good candidates must be not demented, psychiatrically stable, & still demonstrating good symptom relief from meds, but with inconsistent results.
Could deep brain stimulation develop to become a cure for diseases such as alzheimer's and parkinson's?
Control measure. Dbs is not a cure currently and doubtful it will be a panacea. Yet, valuable when meds start failing in parkinson's but not yet in use for alzheimer's.
Watch for updates. Dbs for alzheimer's is a field with a lot of research being done. It is hard to predict what will be the outcome. There are some preliminary data from hopkins that shows promise. There is also a big initiative to study this further and there are formal clinical trials in the works.
No. DBS just modifies the neural circuitry to optimize the output of brain. It does not affect the genes or cells on a structural level. Cell based therapies in future could cure these diseases.
No, but very helpful. Deep brain stimulation therapy of the stn (sub-thalamic nucleus) or gpi (globus pallidus interna) can greatly improve "on" time (good function with minimized symptoms) & greatly reduce dyskinesia (twisting, writhing, jerking movements during "on" time). Good candidates must be not demented, psychiatrically stable, & still demonstrating good symptom relief from meds, but with inconsistent results.
DBS & PD. Deep Brain Stimulation (DBS) can not cure Parkinson's Disease (PD). However, DBS can significantly help the symptoms such as tremor, rigidity & bradykinesia (slowness of movement). DBS does allow patients to significantly reduce the dosage or number of PD medications they are taking. DBS increases the quality of life in PD, however, patient selection is very important since it is not for everyone.
Hours of relief! Dbs is relatively a new intervention: surgically implanted electrical stimulator to a specific area in the brain, this procedure can bring hours of relief from symptoms of parkinson's. Its not a replacement for medications. This procedure is usually recommended when the patient's responsivity to drug treatment begins to decrease.
We don't fully know. But the wires are placed into deep basal ganglia nuclei and the electrical impulses stimulate the electrochemical discharges and basically help management of fluctuations and varying symptoms. One item of interest is absence of benefit if unresponsive to L-DOPA, so, obviously, this is one potential explanation, but not all to it.
Electrical stim. This involves an exacting neurosurgical procedure and wire placement is critical, but the device can control tremors, imbalance, and on-off deterioration, and might remarkably transform capacity of advanced patients to function.
Parkinson's disease. Deep brain stimulation surgery has become an excellent adjunct treatment of Parkinson's disease but it is reserved for patients that have failed medical treatment and are continuing to worsen with their symptoms.