A recent hand X-ray noted "demineralization." I have osteoporosis from 20 years of depakote. Are the demineralization and osteoporosis related?

Yes. Demineralization means loss of minerals like calcium, phosphorus ; magnesium. In osteoporosis the bone formation is less than bone loss. Bone loss is due to minerals loss. This makes bone less dense and brittle; prone to fx. Happens in postmenopausal woman ; >60 y man. Depakote causes osteoporosis in 0.41%. Recent study shows out of 28388 persons, only117 had osteoporosis. Your CML causes osteo.