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Is hirschsprung's disease hereditary?

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Dr. Gerald Mandell
Nuclear Medicine

In brief: Some familial cases

Disease can be familial or develop spontaneously.
It is more common in boys than girlls.Approximately 3-5 % of male siblings and 1 percent of female siblings of children with short-segment disease also have the disease.Risk substantially higher (12.4-33%) in siblings of children with total colonic involvement.Eight genomes have been associated with Hirschsprung’s disease.Most cases not familial.

In brief: Some familial cases

Disease can be familial or develop spontaneously.
It is more common in boys than girlls.Approximately 3-5 % of male siblings and 1 percent of female siblings of children with short-segment disease also have the disease.Risk substantially higher (12.4-33%) in siblings of children with total colonic involvement.Eight genomes have been associated with Hirschsprung’s disease.Most cases not familial.
Dr. Gerald Mandell
Dr. Gerald Mandell
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