What is high anion gap metabolic acidosis?

Metabolic acidosis. A high anion gap acidosis, (h), is an acidosis with a low carbon dioxide (c) and a normal chloride. This low c indicates the presence of an organic acid, such as lactic acid. H is seen in sepsis and diabetic ketoacidosis, among other conditions. It is a serious condition that requires immediate medical therapy to resolve it, as it is often life-threatening.

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How does high chloride cause a (non-anion gap) metabolic acidosis?

See below. Please consult this site for the information. It is more involved than the 400 characters will allow. http://emedicine.medscape.com/article/240809-overview. Read more...