How safe is doctors office for blepharoplasty?

Depends on facility. Facial and eyelid surgery should only be done in accredited facilities. These are offices that have passed certification exams that are given by various agencies. This will help you to find a facility and a surgeon that puts your safety first.
Find a safe facility. A board certified physician, with the appropriate facial plastic surgery training and a well equipped and staffed minor procedure room can safely perform eyelid surgery. This can reduce the costs associated with a surgery center. Just do your homework on the facility first to ensure it is accredited and that proper safety and sterility precautions are followed.
Be careful. Plastic surgeons that are members of the american society of plastic surgeons asps only operate in accredited facilities. Be sure your surgeon has hospital privileges to perform your surgery. Hospitals verify credentials of the staff physicians.
Safe. Upper lids are easily done in an office setting, while lower lids are a little trickier as they are typically more involved. Your surgeon can counsel you about the options.
Usually very safe. Blepharoplasty is performed under local anesthesia so in an office based surgical facility it can be performed very safely as long as the surgeon is capable and has screened patients properly. I have performed over 10000 blepharoplasties in office setting and local anesthesia without encountering a single problem.
Office Eyelid Safety. Since office upper blepharoplasty is usually performed under local anesthesia, it is very safe.