What's the difference between primary biliary cirrhosis and primary sclerosing cholangitis?

Similar symptoms. Distinct diseases that announce themselves in the same way. Both destroy the small bile ducts within the liver and produce jaundice, itching and sometimes failure of the liver. The microscopic picture, labs, and treatment options are as strikingly different as the presentations are similar.

Related Questions

Why is igm elevated in primary biliary cirrhosis (cholangitis)?

Immune dysregulation. The immune system is not functioning normally in primary biliary cirrhosis. That and the chronic inflammation contrive to raise IgM. Read more...

Does primary sclerosing cholangitis show up in blood work? I'm itching all over my body. What can I do?

High bilirubin level. This can cause high bilirubin levels, which can make you itch. Benadryl (diphenhydramine) may help a little. Call your doc that made this diagnosis or follows you for it; you made need new lab work if it's been a while. Read more...

Does primary sclerosing cholangitis usually cause many symptoms?

It can. Primary sclerosing cholangitis (= psc, inflammation of bile ducts) can give symptoms such as itching, pain in the right upper abdomen, fevers, chills, night sweats, and jaundice (yellow skin, yellow whites of the eyes). Most people with this illness have ulcerative colitis, which has symptoms of its own (eg. Bloody diarrhea, abdominal pain). Many with psc eventually need liver transplant. Read more...

Do doctors see a lot of patients with primary sclerosing cholangitis?

No. Primary sclerosing cholangitis is a rare disease affecting 6 out of 100, 000 people in the USA. It is more common in men then in women, and the mean age at diagnosis of is around 40 years of age. Read more...

He has gallstones and maybe with psc (primary sclerosing cholangitis). He's had constant pain in his upper right quadrant for 24hr+. Do we go to emerg?

RUQ pain. If he is known to have gallstones, i would go to an urgent care/ primary physician office to get liver enzymes checked as well as an ultrasound of the liver and biliary ducts done to make sure he has no biliary obstruction from stones. Read more...

I have a 16 year old female friend with primary sclerosing cholangitis. If she is on the liver transplant list, what is her prognosis?

LIVER TRANSPLANT. If she is on the liver transplant list, her prognosis is guarded unless she gets a transplant. Read more...
Depends on donors. Placement on the national wait list for a deceased donor liver means that she is not expected to survive without transplantation. Her life will depend on the generosity of others who agree to donate their organs. Unfortunately there is a severe shortage with 18 deaths per day in the us. Her outlook is bright if she does get a liver in time. Read more...
Very good. Patients with primary sclerosing cholangitis, or psc, are among the patients who have the best long-term outcomes following liver transplantation. Young people with psc, such as your friend, do particularly well. The likelihood that she will be alive 5 years after transplant is likely greater than 80%, and there are many examples of patients like her alive 10-20 years or more after transplant. Read more...

Do people with primary sclerosing cholangitis have a lot of pain?

Depends. Primary sclerosing cholangitis ( psc) causes destruction of the bile ducts inside and outside of the liver. The first symptoms of the disease include fatigue, itching and jaundice, or yellowing of the skin and eyes. Psc however, is associated with a number of hepatobilliary disorders like pancreatitis, which may cause pain. Read more...
Not common. Most people with psc don't routinely complain of pain. Psc affects the bile ducts and can lead to cirrhosis of the liver. This can cause many things jaundice, itching, fatigue, bleeding. I suppose if you still have your gallbladder you could have some pain from obstruction of the outflow of the gallbladder. But pain isn't the first thing i think of with psc. Read more...