2 doctors weighed in:

Cymbalta (duloxetine) 60mg..Coerg 6.25 total daily.Does cymbalta (duloxetine) raise coreg levels.And vice versa..What are interactions..Can they be taken together or spaced out?

2 doctors weighed in
Dr. Donald Jacobson
Psychiatry
1 doctor agrees

In brief: Yes, they interact

Using Carvedilol together with duloxetine can increase the effects of either medication.
If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications. www.drugs.com. The special tests would include liver isoenzymes for the cyp2d6 isoenzyme.

In brief: Yes, they interact

Using Carvedilol together with duloxetine can increase the effects of either medication.
If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications. www.drugs.com. The special tests would include liver isoenzymes for the cyp2d6 isoenzyme.
Dr. Donald Jacobson
Dr. Donald Jacobson
Thank
Dr. James Wells
Psychiatry
1 doctor agrees

In brief: Relatively minor

It is my understanding that Cymbalta (duloxetine) can increase the level of Coreg by inhibiting liver enzyme involved with Coreg metabolism. When taken probably doesn't matter, since it's not an absorption issue.
The inhibition of the liver enzyme isn't likely to be much different from hour to hour once Cymbalta (duloxetine) reaches its regular level for the dose being taken. Provider of Coreg should monitor its effects.

In brief: Relatively minor

It is my understanding that Cymbalta (duloxetine) can increase the level of Coreg by inhibiting liver enzyme involved with Coreg metabolism. When taken probably doesn't matter, since it's not an absorption issue.
The inhibition of the liver enzyme isn't likely to be much different from hour to hour once Cymbalta (duloxetine) reaches its regular level for the dose being taken. Provider of Coreg should monitor its effects.
Dr. James Wells
Dr. James Wells
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1 comment
Dr. James Wells
Coreg provider should know what to monitor, but included in the list is BP, pulse, hgb A1C, (all for potentially being too low), thyroid function (for potentially being too high), and liver function. Be sure to report dizziness, fainting, wheezing, shortness of breath, cold fingers or toes and other changes in symptoms of any kind.
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