Is there a chicago rehab clinic that can deal with prescription drug dependence, underlying depression?

Yes--there are many. It is very common for people who struggle with drug dependence to also have depression, anxiety issues or post-traumatic stress disorder. Although chicago has many good rehab clinics, i would recommend you looking at the hazelden program. Hazelden programs are located throughout the country and have helped thousands of men, women & youth learn to live a meaningful life.