6 doctors weighed in:

What is (are) the mechanism(s) by which benzodiazepines reduce norepinephrine release?

6 doctors weighed in
Dr. Pamela Pappas
Psychiatry
2 doctors agree

In brief: Benzodiazepines

Benzodiazepines do not directly reduce norepinephrine release, but they do enhance the inhibitory gaba-a receptor function in the brain so that nerve cells downstream will be less active -- including norepinephrine-firing ones.
The end effect is sedation, emotional calming, decreased muscle tone and coordination, decreased memory function, and a host of other changes.

In brief: Benzodiazepines

Benzodiazepines do not directly reduce norepinephrine release, but they do enhance the inhibitory gaba-a receptor function in the brain so that nerve cells downstream will be less active -- including norepinephrine-firing ones.
The end effect is sedation, emotional calming, decreased muscle tone and coordination, decreased memory function, and a host of other changes.
Dr. Pamela Pappas
Dr. Pamela Pappas
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