What is the quickest way to get rid of a very high fever?

Evaporative methods. More importantly, determine cause- 1. Adverse drug event: stop the medication; reverse if possible (e.g. Dantroline) 2. Drug-drug interaction: stop the medications if possible; supportive mgmt. 3. Infection: source control, appropriate antibiotics. 4. Environment: remove pt from source.;supportive mgmt.