What are the glands and hormones out of balance in cushing syndrome?

Adrenal dysfunction. The most common form of cushing syndrome is due to taking glucocorticoid rxs (hormones such as prednisone, hydrocortisone) to treat asthma, arthritis, inflammatory bowel, etc. In the less common endogenous cushing syndrome, the adrenal gland (either one or both) produces too much cortisol hormone. This can be due to an over-acive tumor in the adrenal, or in pituitary gland that controls adrenals.