Can OPK detect pregnancy if the hpt is negative?

You are not pregnant. I am not sure what you mean by using these acronyms. Opk to a physician is 'ovulation predictor kit". There is nothing in the ovulation prediction process that tests for pregnancy. The home pregnancy test, if done after one misses a period or has a delayed period is a very accurate and valid way to test for pregnancy. If you doubt the hpt and have not had your period then there is blood tests.