Are smart but uneducated people more prone to drug or alcohol abuse?

Not necessarily. Drug or alcohol abuse is linked more to genetics rather than education or being "smart". The access to treatment has been linked more to socio-economic status (ses) with people of higher ses having more access. Ses is linked to education. Thus, while drug abuse proper is not directly linked to education or being "smart", the access to treatment might be connected to the level of education.