Do all mthfr gene mutations benefit from folate over folic acid? Or certain stands? Is there different treatment for heterozygous v homozygous?

MTHFR . MTHFR has several forms. And treatments can vary. Look here for additional information. http://mthfr.net/mthfr-c677t-mutation-basic-protocol/2012/02/24/
Depends. Folic acid = synthetic. Methylfolate = natural. Folic acid also decreases folate receptors on cells and decreases folate binding proteins (this is bad). Avoid folic acid. Buy Solgar brand methylfolate 800 mcg or other brand. See how you feel in the am. If tired and foggy headed, take one methylfolate. More info: Http://drfairchild.blogspot.com/2013/10/mthfr.html .
What mutation? The pathology community is divided over mthfr testing. I'm undecided. A majority of people who take the test will be told they have an 'abnormal' result and are therefore in need of special supplements which they may then be offered by the folks who have done the test. Talk with your own physician and if necessary an authentic genetic counsellor.
Need activated folat. You need to take methyl tetrahydrofolate (folic acid) to bypass your genetic abnormality or take massive doses of folate (folic acid)--such as 3 grams. You can determine what is adequate by measuring your homocysteine level. Folic acid and folate (folic acid) are the same thing. You may be thinking about folinic acid., .

Related Questions

I am pregnant and have a mthfr gene mutation and I recently read that folic acid is not good for me or the baby and I should take folate instead?

Folic acid is folate (folic acid) Folic acid and folate are the same compound. Follow your gynecologists and hematologists recommendations. Folate is often prescribed during pregnancy in the field of psychiatry and neurology when patients are on anticonvulsants. I too have the same mutation that you have and i take folate every day. I have also been advised to take vitamin b6 and vitamin b 12 because of this. Your child should also be tested for this mutation and anyone else in your family.Best wishes. Read more...
MTHFR. If you've been tested for mthfr mutations and do have one, then your body may not do well with Folic Acid at all. You would benefit more from methylfolate since it bypasses the metabolic step that your system has trouble with. You need a functional medicine or integrative medicine doc who really knows mutations in this enzyme ; can advise you plus collaborate with your ob-gyn doc too. Read more...
Folic acid is bad. Folic acid is synthetic folate, and needs extra metabolic steps to turn it into a usable form. The body is very slow to convert it, and unmetabolized folic acid downregulates your folate receptors and folate binding proteins. This is a bad thing. Avoid folic acid, and take methylfolate instead. Read more...

Does heterozygous for MTHFR gene mutation affect pregnancy?, and what about taking synthetic folic acid supplement?

Controversial... Some studies have shown an association between the MTHFR gene mutation and recurrent miscarriages but this is controversial. Aside from this possibility, it doesn't cause problems with pregnancy. If you have this mutation, its a good idea to take folic acid, vitamin B-12 and Vitamen B-6. Aspirin is also sometimes recommended for women for who have had recurrent miscarriages. Best wishes! Read more...

Is there a benefit in taking folate over folic acid for all mthfr or only certain strands? Is treatment different for homozygous v heterozygous?

Homozygous. For mthfr most treatments are for homozygous. Supplemental folate (folic acid) should be taken. Talk to your doctor and have a family member come with you to write down the answers to your questions. Heterozygous have a copy of normal genes do generally protected. Read more...
Complicated. Mthfr c677t mutation should be treated with methylfolate (and not regular, synthetic folic acid) along with cofactors methyl or hydroxy b12, b2 and b6 most integrative doctors believe that both homozygous and heterozygous should be treated in this manner (unless there are other methylation defects). The a1298c mutation is more likely to affect neurotransmitter production so treatment is different. Read more...

I am hetero for the mthfr genetic mutation c677t. Everything I've read says I should be gluten/folic acid/dairy free. Advice regarding this mutation?

Spectracell lab. In tx has a test for this. Since you are pos. For it, you can visit their site for info or call them. Peace and good health. Read more...
I can't agree. ~1 person in 4 is like you. The pathology community is divided over MTHFR testing. I'm undecided. A majority of people who take the test will be told they have an 'abnormal' result and are therefore in need of special supplements which they may then be offered by the folks who have done the test. Talk with your own physician and if necessary an authentic genetic counsellor. . Read more...
Not so extreme but.. This is common, affecting up to 50% of people,but the homozygous mutation is much more significant than hetero.Those with it have increased risk of depression, anxiety,cardiovascular disease etc. but it's just one of thousands of genes. My best advice is get a fasting homocysteine test; if 10 or higher take a multivit. with the L-5MTHF form of folate. See https://tinyurl.com/yacd86e4 and comment: Read more...

Hi Docs: If + for 2 MTHFR genes, what are possible effects on body from foods high in folate (folic acid)? And is it typical to have lowish (<6) serum folate (folic acid)?

Need more not less! If you have a problem with two MTHFR genes, you actually need folic acid supplementation. Foods high in folate will help you not hurt you. I usually recommend 4mg of folic acid a day, along with 1000ug of B-12 and 100mg B-6 per day and a bab aspirin. Some women with the MTHFR defect have repeated miscarriages. In my experience, the above supplements decrease the risk of this. Best wishes! Read more...

I have mthfr c677t homozygous mutation, history of rectal cancer ([email protected]). Are these related? What is the serum folate (folic acid) level I should aim if want pregnant?

Not related. These are not related. Also recent data shows no clinical significance of having a mrhfr mutation. It is safe for pregnancy and there is no increase risk for miscarriage other than your normal risk factors. Do not need to follow folate (folic acid) or homocysteine levels. Read more...
No. Mthfr 677 does not affect colorectal cancer risk although it can increase risk of certain other cancers. Titrate folate (folic acid) intake to homocysteine level. If homocysteine is between 5-7, your folate (folic acid) intake is adequate. Do not take Folic Acid but rather take metafolin. http://drfairchild.blogspot.com/2013/08/homocysteine.html. Read more...
Junk science. Forgive my frankness. C677t is a no big deal & 10% of folks are like you. Eat sensibly &/or take folate (folic acid) if you want to conceive like anyone else. The push for mthfr typing is the work of a militant lab & i doubt its usefulness. I saw the little study from red china correlating this allele to lung cancer; it makes no sense biologically and the numbers are barely significant; i'm ignoring it. Read more...

Dr. Chevies newman, does mthfr mutation prevent body from processing folic acid or doing it well? I hear it takes time to build up folate. As I didn't start that early, I am worried about neural tube defects.

He's right but... Since you are heterozygous you will be able to convert some Folic Acid to the active l-5-mthfr form. Also, hopefully your diet had adequate folate (folic acid) from green leafy veggies etc. Because 30% of people have folate (folic acid) metabolism issues i advise women to take prenatals that have the l-5-mthf form. If worried you can get imagining studies to check for neural tube defects. Read more...
MTHFR Heterozygote. Being a heterozygote for mthfr is quite common. I'm glad you are on folate (folic acid) now, but this should not increase your risk of ntd over the baseline population, as your serum folate (folic acid) is almost certainly normal. Read more...
Hi, I think I answer. Your question incorrectly earlier. I reviewed the mutation, not an issue with clotting, couldn't get back to change answer. I'm not aware of this gene as causative for neural tube defects, the issue is mostly theoretic and any increase would be minimal. Neural tube defect numbers are smaller than the heterozygous mtfhr mutation rate, nevertheless i would recommend l-methylfolate during 1st 8wk. Read more...

Hi, I'm not really sure how this service works, but I'm going to send my question and see what happens. I have been having fertility treatment and was recently diagnosed with the homozygous C665T MTHFR gene mutation. There is a lot of conflicting inform

Sorry I. cannot offer more help than this: The "story" is still "OUT" and this gene abnormality has now been blamed for just about EVERYTHING from early heart disease to frequent miscarriages! I would be VERY CAUTIOUS about accepting ANY ADVICE particularly the INTERNET about this "condition" If this is a MAJOR issue consult with a Board Certified GENETICIST! My Opinion only...hope it helps..Good Luck Z. Read more...
Fasting homocysteine. This is a controversial an evolving issue. Most Obgyns would treat you with Heparin or Lovenox (enoxaparin) with a homozygous MTFHR mutation. The most up to date literature suggests testing a fasting homocysteine level and then only treating those who fail. Personally I base treatment of homozygous carriers on their past history of miscarriage or poor pregnancy outcome and infertility. Read more...
Habitual Miscarriage. There is much controversy surrounding this gene and the medical literature doesn't agree. However, personally, I have treated many women who repeatedly miscarry, and can't carry a baby to term, who responded (and carried to term) when treated. One treatment consists of taking daily an aspirin, Vitamin B-12, Vit B-6, and high-dose folic acid. Low-dose heparin is also sometimes used. Read more...

Diagnosed homozygous for MTHFR mutation, proscribed 5mg Folic acid. Should I be taking Methylfolate instead?? What about B6 & B12?

Get several opinions. The pathology community is divided about this. You already know that a majority of seemingly-healthy people who are tested for MTHFR will be told they are "abnormal" & need special Rx. The lab that pressures physicians to order MTHFR testing may also contact these people to sell them nutritional supplements. If you are concerned, speak with a subspecialist and/or a clinical geneticist. Read more...