Ana 1280 speckled what are all possible causes? Is there any way it could not be a connective tissue disorder?

See details. There are too many possible causes to even begin to list them. The ANA must be evaluated in the context of the clinical symptoms. If your symptoms suggest a connective tissue disorder then the ANA is strong evidence confirming the diagnosis. If they do not, look for other causes. Have a rheumatologist evaluate the issue if you have not done so already.