Can using a mouse continuously for 12 hours per day lead to damage to the hand so that it becomes unusable?

R S I. (rsi) known as "repetitive stress injury", "repetitive motion injuries", "repetitive motion disorder", "cumulative trauma disorder", "occupational overuse syndrome", "overuse syndrome", is an injury of the musculoskeletal and nervous systems that may be caused by repetitive tasks, forceful exertions, vibrations, mechanical compression (pressing against hardsurface)sustained, or awkward positions.