3 doctors weighed in:

Sickle cell disease bone marrow transplant. Is that working out or not?

3 doctors weighed in
Dr. Juan Sanabria
Surgery - Transplant
1 doctor agrees

In brief: No clear results.

There is not level 1 evidence to show bone marrow transplant increases survival in patients with sickle cell disease.
Although there are several reports with success a systematic randomized trial remains to be done. Bone marrow transplant is a procedure with multiple complications. After the procedure the recipient has to take meds for life. Cost/effective therapy analyses are not present.

In brief: No clear results.

There is not level 1 evidence to show bone marrow transplant increases survival in patients with sickle cell disease.
Although there are several reports with success a systematic randomized trial remains to be done. Bone marrow transplant is a procedure with multiple complications. After the procedure the recipient has to take meds for life. Cost/effective therapy analyses are not present.
Dr. Juan Sanabria
Dr. Juan Sanabria
Thank
Dr. Scott Diede
Pediatrics - Hematology & Oncology

In brief: For select patients

Bone marrow transplant can cure patients with sickle cell disease, however this procedure has significant risks (including death).
There is emerging evidence that the earlier one is transplanted for sickle cell disease, the better the outcome. This is a difficult decision to make since many with sickle cell have mild disease. Deciding who should be transplanted and when is not straight forward.

In brief: For select patients

Bone marrow transplant can cure patients with sickle cell disease, however this procedure has significant risks (including death).
There is emerging evidence that the earlier one is transplanted for sickle cell disease, the better the outcome. This is a difficult decision to make since many with sickle cell have mild disease. Deciding who should be transplanted and when is not straight forward.
Dr. Scott Diede
Dr. Scott Diede
Thank
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