Was on many medications for confirmed MS (rebif, copaxone, gilenya, tysabri, (natalizumab) tecfidera) none helped control. Is this typical of ms? Next step?

Challenging. This is quite unusual, and makes me wonder whether indeed you have MS or a condition which might mimic MS. Would suggest full reassessment including testing for neuromyelitis optica (aquaporin 4), evaluations for Lyme disease, CADASIL, vitamin B-12 and vitamin D deficiencies, perhaps syphilis and HIV, maybe anti-phospholipid antibody syndrome.