Equal. Men and women are equally likely to suffer from a substance use disorder. However, women are more likely to suffer serious complications of alcoholism earlier than men.
Similar. Men are more likely than women to have opportunities to use drugs, but men and women given an opportunity to use drugs for the first time are equally likely to do so and to progress from initial use to addiction. However, women and men appear to differ in their vulnerability to some drugs. Both become addicted to cocaine, heroin, hallucinogens, tobacco. Difference -women > sedatives, men > alcohol.